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| International Anorexia Nervosa Treatment Study |
The focus of this study is outpatient treatment for adolescent anorexia nervosa (AN). Successful early treatment is likely to reduce the prevalence of chronic AN with its high rates of morbidity and mortality and high health care costs. Family therapy appears to be an effective way of addressing this problem, but it is unclear which type of family therapy is most effective, Hence, this large-scale study compares two types of family therapy: Behavioral Family Therapy (BFT), which focuses on the symptoms of anorexia nervosa; Systems Family Therapy (SFT), which focuses on family functioning. Participant families will be randomly allocated to one of the two family therapies. In addition there is some evidence that fluoxetine (prozac) may be beneficial in reducing symptoms associated with anorexia nervosa such as depression and anxiety, and may be helpful in maintaining progress after family therapy has ended. Because there has been no controlled trial of fluoxetine in adolescent anorexia nervosa, participants in this study will also be randomly allocated to either fluoxetine or placebo.
We are looking for girls and boys aged 12-18 years who are underweight and appear to be excessively preoccupied with their weight and/or shape. Those who qualify and choose to participate will be randomly allocated to one of four groups: SFT + fluoxetine; BFT + fluoxetine; SFT + placebo; BFT + placebo. Family therapy will consist of 16 one hour sessions over a 9 month period and medication will be given for 15 months under close medical supervision. Participants will also be asked to come back for assessments at the end of family therapy, and again at 6 and 12-months intervals following the end of family treatment.
In a sub-study blood will be drawn from those volunteering for genetic analysis focusing on the subset of non-responders to treatments, this is optional.
If you are interested in finding out more about this study and live in or around the cities listed below, please contact them for more information.
Baltimore, MD:
Center for Eating Disorders
Sheppard Pratt Health System
(410) 427-3854
New York, NY :
Eating Disorders Research Program
Weill Medical College of Cornell University
(914) 997-4395
Saint Louis, MO:
Washington University School of Medicine
(314) 286-0076
San Diego, CA:
UCSD, Eating Disorder Treatment
and Research Program
(858) 366-2525
Toronto, ON, Canada:
Toronto General Hospital
(416) 340-4800 ext. 3894
Tulsa, OK:
Laureate Psychiatric Clinic and Hospital
(918) 491-3722
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